The Zetasizer Nano ZS from Malvern Instruments enables the measurement of both particle size, from 0.6nm to 6000 nm, and zeta potential in a single instrument. 'Being able to measure particle size is important for the determination of the hydrodynamic radius of the particles including the polymer shell in comparison to other methods like TEM, visualising the particle radius without polymer shell' said Dr Kosmella.

With the Zetasizer Nano the researchers were able to show that the average diameter of the particles was less than 5 nm and to determine the zeta potential of the dispersion, an indicator of its stability. This results in a dispersion of gold nanoparticles, which turn the solution red. To make the particles, a mixture of gold chloride and PEI in solution is heated to 100 degC. The PEI is a polyelectrolyte that acts as a reducing agent as well as a stabilising agent. Sabine Kosmella and Joachim Koetz made the ultrafine nanoparticles in a one-step reaction using gold chloride and an oligosaccharide-modified hyper-branched polyethylenimine (PEI). This makes gold nanoparticles interesting for life science applications, in tagging viruses and cells for example. For particles under 5 nm the surface electrons increasingly dominate the properties of the surface and consequently of the system. Gold has long been considered as an inert element, but in nanoparticulate form it can be very reactive. Particle size distribution, particle shape information, zeta potential, molecular weight, chemical compos These particle analysis systems deliver industrially relevant data enabling our customers to make the connection between micro (such as particle size) and macro (bulk) material properties (rheology) and chemical composition (chemical imaging). The broad portfolio of innovative technologies is combined with intelligent, user-friendly software. Malvern has a growing portfolio of patented particle analysis technologies, and the company's in-depth industry applications knowledge enables customers to achieve their competitive advantage.ДЄnalytical instrumentation from Malvern are used in the characterization of a wide variety of materials, from industrial bulk powders to the latest nanomaterials and delicate macromolecules. The company provides a range of particle analysis and rheological instrumentation that delivers inter-related measurements reflecting the complexities of particulates and disperse systems, nanomaterials and macromolecules. Do not transfer samples from container to container, which introduces dusts and bubbles.Malvern Instruments recognizes and supports industry's continuing drive to optimize the products it produces and the processes it employs. * () Please avoid dusts or contaminate when preparing your sample. * () Cuvettes should be rinsed and sonicated in your buffers and/or ddH2O before applying samples for measurements. Static Light Scattering for Mw measurementД®quipped with MPT-2 autotitrator and temperature control system, the Zetasizer Nano is capable for pH titration, sample dilution and injection, temperature trend measurements and melting point studies.ДЇor more detail, please visit Malvern website. Dynamic Light Scattering for Particle Size measurementДў. Malvern Zetasizer combined 3 major techniques:ДЎ.

Malvern zetasizer zs nano